The Leeds-based company is to introduce flights from Glasgow to Verona from next summer.
The seasonal flights are due to operate between the two cities on Wednesdays.
A spokesman for Glasgow Airport said the announcement was “welcome news” for passengers.
He said: “The introduction of this additional service to the beautiful city of Verona will be welcome news for those passengers keen to explore Northern Italy next summer.”
The new route is on top of Glasgow Airport’s Jet2 summer 24 programme that was recently expanded to five destinations, including Ibiza, Izmir, Reus, Bodrum and Rhodes.
The airline was forced to cancel all its flights to Rhodes over the weekend as wildfires continue to rage across Greece.
It was revealed earlier in the month that revenues at airline and leisure group Jet2 have rebounded following renewed consumer confidence.